Protein profile

PA4957

phosphatidylserine decarboxylase

Genome: NC_002516.2

Gene: PA4957 psd Structure source: AlphaFold UniProt Q9HUK8
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Amino acids 289
Annotations 5
Features 11
PDB binders 3
Druggability 0.742

Overview

Basic information about this protein and its source genome.

Accession
PA4957
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4957 psd
Status
annotated
Amino acids
289
Structure source
AlphaFold
EC
4.1.1.65
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004609 Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine. GO:0006646 The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.259
Human E-value
2.56e-11
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.742
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSFKDRLFICSQYLLPHHLLSRLIGFAADCRATWFKDRLIAWFARRYQVDMREAQVEDLQAFEHFNAFFTRALKDGARPLAQEPGAVLCPADGAISQLGPIEHGRIFQAKGHSYSLAELLGGDAELAAPFMGGDFATVYLSPRDYHRVHMPLAGTLREMVYVPGRLFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASIETVWAGLVTPPKRELKTFRYDEAARAPIRLEKGAELGRFKLGSTAIVLFGPQQVAFNDGLGAASPVRMGECLALPKQS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004609 Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.
  • GO:0006646 The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
  • GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
51 285 NCBIfam TIGR00163 archaetidylserine decarboxylase
51 285 InterPro IPR033177 Phosphatidylserine decarboxylase, bacterial/eukaryotic
12 287 Hamap MF_00662 Phosphatidylserine decarboxylase proenzyme [psd].
12 287 InterPro IPR033178 Phosphatidylserine decarboxylase, prokaryotic type 1
13 285 PANTHER PTHR10067 PHOSPHATIDYLSERINE DECARBOXYLASE
13 285 InterPro IPR003817 Phosphatidylserine decarboxylase-related
65 283 Pfam PF02666 Phosphatidylserine decarboxylase
65 283 InterPro IPR003817 Phosphatidylserine decarboxylase-related
221 289 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
198 220 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 197 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4957
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.742
1 0.62
2 0.519
5 0.202

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
PEE
6L07
P0A8K1 744.0 Da LogP 11.61 TPSA 134.4 2 viol. ✓ Clean CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN…
PPI
6L07
P0A8K1 74.1 Da LogP 0.48 TPSA 37.3 ✓ Ro5 ✓ Clean CCC(=O)O
PYR
6L07
P0A8K1 88.1 Da LogP -0.34 TPSA 54.4 ✓ Ro5 ✓ Clean CC(=O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.