Protein profile

PA4961

hypothetical protein

Genome: NC_002516.2

Gene: PA4961 Structure source: AlphaFold UniProt Q9HUK4
Export view
Amino acids 512
Annotations 1
Features 12
PDB binders 0
Druggability 0.763

Overview

Basic information about this protein and its source genome.

Accession
PA4961
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4961
Status
annotated
Amino acids
512
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.763
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTRPTSVKPDNFFLLLFRALRQRRVPIALRLASHSLILVALALLIYAWVMGMQFRQAMQQQADALGQSLITQTAASATELLVSNDILSLNVLLNNLVKNPLVAHAAIYSVDQRILAEAGSRPKQSLLGATEGLYSTPITFQEVIAGHLRISLDMQQFQQPMMISLQSMGLISLILLILALYFSLRLGRQISTPLLQLRVWLRDPDNPAPGAELQNELGDLARDLEERLVPEKPPAPEPEEAPLPQNFDDILLEDDEADLRSRKVEASAFEEDDIPLGDALLDETKPVEFTSIDEDPLDQDAFDENGAEAGEQPAAPAAAREPQHSAVLAIQLGAQEQLRRLPRSRLVDLLQRYRDCLEQAARQYKGSLHTLSDGGSLILFHSRDNRADYLTNALCCGELMRALGHALQIEVADSGITLQLQLGLSLGEDLSEQTQADLLLNETVQNALALNQHSRNLLLVERSIADDAVVRERARIRAIASPEGACCVERLLEPYPSMLERQLARMHDRARP

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
210 254 MobiDBLite mobidb-lite consensus disorder prediction
163 184 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
162 184 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 49 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 158 Pfam PF10144 Bacterial virulence factor haemolysin
29 158 InterPro IPR019305 Uncharacterised protein family Smp
185 512 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
289 322 MobiDBLite mobidb-lite consensus disorder prediction
218 234 MobiDBLite mobidb-lite consensus disorder prediction
50 162 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 26 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4961
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.69
3 0.404
1 0.399
8 0.304