Protein profile

PA4991

hypothetical protein

Genome: NC_002516.2

Gene: PA4991 Structure source: Experimental + AlphaFold UniProt Q9HUH4
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Amino acids 391
Annotations 4
Features 9
PDB binders 0
Druggability 0.878

Overview

Basic information about this protein and its source genome.

Accession
PA4991
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4991
Status
annotated
Amino acids
391
Structure source
Experimental + AlphaFold
EC
1.-.-.-
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.878
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
7 313 PANTHER PTHR13847 SARCOSINE DEHYDROGENASE-RELATED
6 104 Gene3D G3DSA:3.50.50.60 -
6 104 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
8 314 Pfam PF01266 FAD dependent oxidoreductase
8 314 InterPro IPR006076 FAD dependent oxidoreductase
138 255 Gene3D G3DSA:3.50.50.60 -
138 255 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
7 282 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
7 282 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5EZ7
X-ray 2.40 Å A
100.0% 1-391
PDBe RCSB PDBj File
Viewing
AlphaFold PA4991
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.773

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.06 0.929
2 13.11 0.674
3 1.43 0.019