Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5002
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5002
Status: annotated
Amino acids: 472
Structure source: AlphaFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016811 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0006506 The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.669

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MSARKQQLLKRHRRNKRIGLLVALLALLAVGLLVSPWLLPILLVALWVAHEAWFADHLFYSPGEDYRYRFAEGVESLPVRLADGRLRVDGELREGDTLVLGIGVRAGWLGRFLEPSVLLEGGAEADAQAFERGVNGLRYLNLTGLAGPLGEGRIRLRGRHCRLVGEPTLWRARHPDYRDRRVMVIAPHADDAELAAFGLYSQAREAWIVTLTAGEIETEHYRRMGLDGIAAARLKGRLRAWDSQAVPTWGGVPAERCVQLGYFCLQLPAMQANPGEVVPSREADLADIRPFRQFNRLRLASDADGLSTWNNLLADLRELILLARPEVIVLPHPHFDPHPDHVRAQEAVREALQGLDWQPQALLHYANHLHDNDRWPMGDAHMGVSLPPLTEECSPLLPWTLALERTRQVDKAMALGMMHDLQPRPPFKRRLRRRLQGWLAGRRWPAYGEDEFMRKAVRRHELFWVESLDGEA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0016811 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
GO:0006506 The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
1	19	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
175	457	Gene3D	G3DSA:3.40.50.10320	-
175	457	InterPro	IPR024078	Putative deacetylase LmbE-like domain superfamily
183	352	Pfam	PF02585	GlcNAc-PI de-N-acetylase
183	352	InterPro	IPR003737	N-acetylglucosaminyl phosphatidylinositol deacetylase-related
170	357	PANTHER	PTHR12993	N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED
170	357	InterPro	IPR003737	N-acetylglucosaminyl phosphatidylinositol deacetylase-related
179	447	SUPERFAMILY	SSF102588	LmbE-like
179	447	InterPro	IPR024078	Putative deacetylase LmbE-like domain superfamily
20	49	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
20	49	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
50	472	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5002	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.669

PA5002