Protein profile

PA5008

hypothetical protein

Genome: NC_002516.2

Gene: GUL26_08345 CAZ10_01430 ALP65_01396 rfaP_1 wapP L4V69_34330 PAERUG_P19_London_7_VIM_2_05_10_03068 PA5008 DT376_13610 Structure source: AlphaFold UniProt Q9S661 UniProt G3XD48

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Amino acids 244

Annotations 3

Features 6

PDB binders 1

Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession: PA5008
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: GUL26_08345 CAZ10_01430 ALP65_01396 rfaP_1 wapP L4V69_34330 PAERUG_P19_London_7_VIM_2_05_10_03068 PA5008 DT376_13610
Status: annotated
Amino acids: 244
Structure source: AlphaFold

GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. GO:0006468 The process of introducing a phosphate group on to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.
GO:0006468 The process of introducing a phosphate group on to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
135	237	Gene3D	G3DSA:1.10.510.10	Transferase(Phosphotransferase) domain 1
38	212	Pfam	PF06293	Lipopolysaccharide kinase (Kdo/WaaP) family
154	166	ProSitePatterns	PS00108	Serine/Threonine protein kinases active-site signature.
154	166	InterPro	IPR008271	Serine/threonine-protein kinase, active site
35	181	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)
35	181	InterPro	IPR011009	Protein kinase-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5008	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.906
1				0.265

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
G9S	6DFL	Q9HUF7	596.8 Da LogP 4.85 TPSA 162.3	1 viol.	✓ Clean	`CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](C(C)…`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC139175830	0.519	379.5 Da LogP 4.69 TPSA 95.9	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCCC(=O)NCCOP(=O)(O)O`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.