Protein profile

PA5010

UDP-glucose:(heptosyl) LPS alpha 1,3-glucosyltransferase WaaG

Genome: NC_002516.2

Gene: PA5010 waaG Structure source: Experimental + AlphaFold UniProt Q9HUF6
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Amino acids 373
Annotations 3
Features 8
PDB binders 3
Druggability 0.366

Overview

Basic information about this protein and its source genome.

Accession
PA5010
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5010 waaG
Status
annotated
Amino acids
373
Structure source
Experimental + AlphaFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.366
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
183 348 Pfam PF00534 Glycosyl transferases group 1
183 348 InterPro IPR001296 Glycosyl transferase, family 1
3 368 CDD cd03801 GT4_PimA-like
4 363 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
170 335 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
9 169 FunFam G3DSA:3.40.50.2000:FF:000250 Glucosyltransferase I RfaG
9 169 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
152 363 PANTHER PTHR45947 SULFOQUINOVOSYL TRANSFERASE SQD2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8B5S
X-ray 1.95 Å A
99.2% 1-370
PDBe RCSB PDBj File
Viewing
PDB 8B5Q
X-ray 2.00 Å A,B
98.9% 2-370
PDBe RCSB PDBj File
Loaded
PDB 8B62
X-ray 2.02 Å A,B
98.9% 2-370
PDBe RCSB PDBj File
Loaded
PDB 8B63
X-ray 2.20 Å A,B
98.9% 2-370
PDBe RCSB PDBj File
Loaded
AlphaFold PA5010
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.366

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 41.14 0.965
2 4.32 0.179
3 1.62 0.026
4 1.51 0.022

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
LIP
3C4V
Q8NTA6 258.1 Da LogP -4.98 TPSA 173.6 ✓ Ro5 ✓ Clean [C@H]1([C@@H](C([C@H]([C@@H](C1O)O)O)OP(=O)([O-…
MLT
3MBO
Q81ST7 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O
U2F
2IW1
P25740 568.3 Da LogP -3.82 TPSA 276.8 3 viol. ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.