Protein profile

PA5027

hypothetical protein

Genome: NC_002516.2

Gene: PA5027 Structure source: AlphaFold UniProt Q9HUE2
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Amino acids 271
Annotations 2
Features 19
PDB binders 0
Druggability 0.879

Overview

Basic information about this protein and its source genome.

Accession
PA5027
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5027
Status
annotated
Amino acids
271
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.879
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
139 269 CDD cd00293 USP_Like
1 128 Gene3D G3DSA:3.40.50.620 HUPs
1 128 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
133 269 SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like
1 124 SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like
129 271 Gene3D G3DSA:3.40.50.620 HUPs
129 271 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
231 243 PRINTS PR01438 Universal stress protein signature
231 243 InterPro IPR006015 Universal stress protein A family
133 151 PRINTS PR01438 Universal stress protein signature
133 151 InterPro IPR006015 Universal stress protein A family
249 271 PRINTS PR01438 Universal stress protein signature
249 271 InterPro IPR006015 Universal stress protein A family
191 270 PANTHER PTHR46268 STRESS RESPONSE PROTEIN NHAX
4 125 CDD cd00293 USP_Like
133 270 Pfam PF00582 Universal stress protein family
133 270 InterPro IPR006016 UspA
1 124 Pfam PF00582 Universal stress protein family
1 124 InterPro IPR006016 UspA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5027
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.879