Protein profile

PA5030

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA5030 Structure source: AlphaFold UniProt Q9HUD9
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Amino acids 438
Annotations 4
Features 50
PDB binders 0
Druggability 0.899

Overview

Basic information about this protein and its source genome.

Accession
PA5030
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5030
Status
annotated
Amino acids
438
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.899
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
20 40 Coils Coil Coil
197 219 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
340 363 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
306 316 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
401 423 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 135 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 427 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
44 427 InterPro IPR020846 Major facilitator superfamily domain
168 187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
317 334 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
335 339 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
375 398 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
399 403 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
50 72 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
404 423 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
192 196 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
39 424 SUPERFAMILY SSF103473 MFS general substrate transporter
39 424 InterPro IPR036259 MFS transporter superfamily
114 133 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
139 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
424 438 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
52 360 Pfam PF07690 Major Facilitator Superfamily
52 360 InterPro IPR011701 Major facilitator superfamily
173 191 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
220 252 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
103 113 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
71 75 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
162 172 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
87 106 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
317 334 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
50 409 CDD cd17324 MFS_NepI_like
275 285 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 425 PANTHER PTHR43271 BLL2771 PROTEIN
197 219 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
283 305 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
41 424 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
41 424 InterPro IPR036259 MFS transporter superfamily
339 361 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 49 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
102 118 ProSitePatterns PS00216 Sugar transport proteins signature 1.
102 118 InterPro IPR005829 Sugar transporter, conserved site
364 374 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
286 305 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
253 274 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
50 70 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
76 102 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
139 161 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
374 396 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
134 138 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
251 273 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5030
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.899
2 0.499
5 0.365