Overview
Basic information about this protein and its source genome.
- Accession
- PA5034
- Gene
- PA5034 hemE
- Status
- annotated
- Amino acids
- 355
- Structure source
- Experimental + AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 69.492
- Human E-value
- 7.95e-20
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Enzyme Commission (EC)
1Gene Ontology (GO)
5- GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
- GO:0004853 Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.
- GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
- GO:0019353 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate.
- GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 5 | 348 | Pfam | PF01208 | Uroporphyrinogen decarboxylase (URO-D) |
| 5 | 348 | InterPro | IPR000257 | Uroporphyrinogen decarboxylase (URO-D) |
| 143 | 159 | ProSitePatterns | PS00907 | Uroporphyrinogen decarboxylase signature 2. |
| 143 | 159 | InterPro | IPR000257 | Uroporphyrinogen decarboxylase (URO-D) |
| 10 | 348 | CDD | cd00717 | URO-D |
| 10 | 348 | InterPro | IPR006361 | Uroporphyrinogen decarboxylase HemE |
| 1 | 354 | FunFam | G3DSA:3.20.20.210:FF:000001 | Uroporphyrinogen decarboxylase |
| 6 | 350 | Hamap | MF_00218 | Uroporphyrinogen decarboxylase [hemE]. |
| 6 | 350 | InterPro | IPR006361 | Uroporphyrinogen decarboxylase HemE |
| 22 | 31 | ProSitePatterns | PS00906 | Uroporphyrinogen decarboxylase signature 1. |
| 22 | 31 | InterPro | IPR000257 | Uroporphyrinogen decarboxylase (URO-D) |
| 1 | 355 | Gene3D | G3DSA:3.20.20.210 | - |
| 1 | 355 | InterPro | IPR038071 | UROD/MetE-like superfamily |
| 4 | 352 | PANTHER | PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED |
| 9 | 348 | NCBIfam | TIGR01464 | uroporphyrinogen decarboxylase |
| 9 | 348 | InterPro | IPR006361 | Uroporphyrinogen decarboxylase HemE |
| 1 | 354 | SUPERFAMILY | SSF51726 | UROD/MetE-like |
| 1 | 354 | InterPro | IPR038071 | UROD/MetE-like superfamily |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
1 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.73 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 12.57 | 0.655 | ||||||
| 2 | 1.88 | 0.037 | ||||||
| 3 | 0.55 | 0.0 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.713 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| 1CP | P06132 | 660.8 Da LogP 4.98 TPSA 212.4 | 2 viol. | ✓ Clean |
Cc1c2[nH]c(c1CCC(=O)O)Cc3c(c(c([nH]3)Cc4c(c(c([…
|
|
| CO2 | P06132 | 44.0 Da LogP -0.58 TPSA 34.1 | ✓ Ro5 | ✓ Clean |
C(=O)=O
|
|
| CP3 | P06132 | 660.8 Da LogP 4.98 TPSA 212.4 | 2 viol. | ✓ Clean |
Cc1c2[nH]c(c1CCC(=O)O)Cc3c(c(c([nH]3)Cc4c(c(c([…
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC4202772 | 0.514 | 211.2 Da LogP 1.35 TPSA 90.4 | ✓ Ro5 | ✓ Clean |
Cc1[nH]c(C(=O)O)c(C)c1CCC(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.