Protein profile

PA5035

glutamate synthase subunit beta

Genome: NC_002516.2

Gene: gltD GNQ48_04105 CAZ10_01280 GUL26_08210 IPC1295_08150 L4V69_34465 PA5035 PAERUG_P19_London_7_VIM_2_05_10_03095 gltD_2 Structure source: AlphaFold UniProt G3XD09 UniProt P95457
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Amino acids 477
Annotations 4
Features 24
PDB binders 5
Druggability 0.453

Overview

Basic information about this protein and its source genome.

Accession
PA5035
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
gltD GNQ48_04105 CAZ10_01280 GUL26_08210 IPC1295_08150 L4V69_34465 PA5035 PAERUG_P19_London_7_VIM_2_05_10_03095 gltD_2
Status
annotated
Amino acids
477
Structure source
AlphaFold
GO
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.21
Human E-value
2.11e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.453
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0046872 Binding to a metal ion.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
261 405 FunFam G3DSA:3.50.50.60:FF:000041 Glutamate synthase, small subunit
325 345 Coils Coil Coil
45 77 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
45 77 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
12 476 PANTHER PTHR42783 GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN
15 152 Gene3D G3DSA:1.10.1060.10 -
15 152 InterPro IPR009051 Alpha-helical ferredoxin
15 165 SUPERFAMILY SSF46548 alpha-helical ferredoxin
33 142 Pfam PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
33 142 InterPro IPR028261 Dihydroprymidine dehydrogenase domain II
17 153 FunFam G3DSA:1.10.1060.10:FF:000004 Glutamate synthase, small subunit
156 464 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase
156 464 InterPro IPR023753 FAD/NAD(P)-binding domain
153 260 Gene3D G3DSA:3.40.50.720 -
153 406 SUPERFAMILY SSF51971 Nucleotide-binding domain
261 405 Gene3D G3DSA:3.50.50.60 -
261 405 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
297 311 PRINTS PR00419 Adrenodoxin reductase family signature
156 178 PRINTS PR00419 Adrenodoxin reductase family signature
331 344 PRINTS PR00419 Adrenodoxin reductase family signature
179 192 PRINTS PR00419 Adrenodoxin reductase family signature
221 231 PRINTS PR00419 Adrenodoxin reductase family signature
14 477 NCBIfam TIGR01318 glutamate synthase, small subunit
14 477 InterPro IPR006006 Glutamate synthase NADPH small chain-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5035
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.38

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AKG
2VDC
Q05756 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
F3S
2VDC
Q05756 295.8 Da LogP 2.59 TPSA 0.0 ✓ Ro5 ✓ Clean S1[Fe]2S[Fe]3[S]2[Fe]1S3
FES
5VJ7
I6V148 175.8 Da LogP 1.29 TPSA 0.0 ✓ Ro5 ✓ Clean S1[Fe]S[Fe]1
ODP
1LQT
P9WIQ3 760.4 Da LogP -3.88 TPSA 381.0 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
OMT
2VDC
Q05756 181.2 Da LogP -1.17 TPSA 97.5 ✓ Ro5 ✓ Clean CS(=O)(=O)CC[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.