Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5037
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5037
Status: annotated
Amino acids: 551
Structure source: AlphaFold

GO

GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.397

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
6	501	PANTHER	PTHR35894	GENERAL SECRETION PATHWAY PROTEIN A-RELATED
282	551	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
360	374	MobiDBLite	mobidb-lite	consensus disorder prediction
49	171	Pfam	PF13401	AAA domain
49	171	InterPro	IPR003593	AAA+ ATPase domain
289	459	MobiDBLite	mobidb-lite	consensus disorder prediction
380	428	MobiDBLite	mobidb-lite	consensus disorder prediction
265	281	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
37	182	Gene3D	G3DSA:3.40.50.300	-
37	182	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
289	319	MobiDBLite	mobidb-lite	consensus disorder prediction
19	246	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
19	246	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
1	264	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
462	539	ProSiteProfiles	PS51724	SPOR domain profile.
462	539	InterPro	IPR007730	Sporulation-like domain
464	528	SUPERFAMILY	SSF110997	Sporulation related repeat
464	528	InterPro	IPR036680	Sporulation-like domain superfamily
450	547	Gene3D	G3DSA:3.30.70.1070	Sporulation related repeat
450	547	InterPro	IPR036680	Sporulation-like domain superfamily
465	537	Pfam	PF05036	SPOR domain
465	537	InterPro	IPR007730	Sporulation-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5037	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.397
2				0.35
8				0.291

PA5037