Protein profile

PA5041

type 4 fimbrial biogenesis protein PilP

Genome: NC_002516.2

Gene: PAERUG_P19_London_7_VIM_2_05_10_03101 IPC1295_08180 GUL26_08180 pilP L4V69_34495 CAZ10_01250 PA5041 DT376_01080 Structure source: Experimental + AlphaFold UniProt G3XCX7 UniProt Q51354
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Amino acids 174
Annotations 4
Features 15
PDB binders 0
Druggability 0.629

Overview

Basic information about this protein and its source genome.

Accession
PA5041
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PAERUG_P19_London_7_VIM_2_05_10_03101 IPC1295_08180 GUL26_08180 pilP L4V69_34495 CAZ10_01250 PA5041 DT376_01080
Status
annotated
Amino acids
174
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0043683 The assembly from its constituent parts of a type IV pilus. GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.629
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.
  • GO:0043683 The assembly from its constituent parts of a type IV pilus.
  • GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
79 171 FunFam G3DSA:2.30.30.830:FF:000001 Type 4 fimbrial biogenesis protein PilP
79 171 Gene3D G3DSA:2.30.30.830 -
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
26 170 Pfam PF04351 Pilus assembly protein, PilP
26 170 InterPro IPR007446 Type IV pilus inner membrane component PilP
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
22 174 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
1 18 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 174 PIRSF PIRSF016481 PilP_PilQ
1 174 InterPro IPR007446 Type IV pilus inner membrane component PilP
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2Y4X
X-ray 1.70 Å A,B
51.1% 83-171
PDBe RCSB PDBj File
Viewing
PDB 2Y4Y
X-ray 1.70 Å A,B,C,D
51.1% 83-171
PDBe RCSB PDBj File
Loaded
AlphaFold PA5041
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.629

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.63 0.026