Protein profile

PA5042

type 4 fimbrial biogenesis protein PilO

Genome: NC_002516.2

Gene: pilO CAZ10_01245 IPC1295_08185 GNQ48_04070 ALP65_02009 PA5042 DT376_01075 PAERUG_P19_London_7_VIM_2_05_10_03102 GUL26_08175 Structure source: Experimental + AlphaFold UniProt G3XD51 UniProt Q51353
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Amino acids 207
Annotations 4
Features 15
PDB binders 0
Druggability 0.807

Overview

Basic information about this protein and its source genome.

Accession
PA5042
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pilO CAZ10_01245 IPC1295_08185 GNQ48_04070 ALP65_02009 PA5042 DT376_01075 PAERUG_P19_London_7_VIM_2_05_10_03102 GUL26_08175
Status
annotated
Amino acids
207
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0043683 The assembly from its constituent parts of a type IV pilus. GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.807
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.
  • GO:0043683 The assembly from its constituent parts of a type IV pilus.
  • GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
103 207 FunFam G3DSA:3.30.70.60:FF:000005 Pilus assembly protein, PilO
50 207 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
26 204 PANTHER PTHR39555 FIMBRIAL ASSEMBLY PROTEIN PILO-LIKE PROTEIN-RELATED
58 202 Pfam PF04350 Pilus assembly protein, PilO
58 202 InterPro IPR007445 Type IV pilus inner membrane component PilO
67 102 Gene3D G3DSA:1.10.287.540 Helix hairpin bin
51 102 Coils Coil Coil
28 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 206 Gene3D G3DSA:3.30.70.60 -
103 206 InterPro IPR014717 Translation elongation factor EF1B/ribosomal protein S6
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 102 FunFam G3DSA:1.10.287.540:FF:000001 Type IV pilus assembly protein PilO
1 206 PIRSF PIRSF016482 PilO
1 206 InterPro IPR007445 Type IV pilus inner membrane component PilO
1 27 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2RJZ
X-ray 2.20 Å A,B
65.7% 69-204
PDBe RCSB PDBj File
Viewing
PDB 5UVR
X-ray 1.70 Å A
47.3% 109-206
PDBe RCSB PDBj File
Loaded
AlphaFold PA5042
AlphaFold — — full sequence — Loaded
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