Protein profile

PA5043

type 4 fimbrial biogenesis protein PilN

Genome: NC_002516.2

Gene: PA5043 GUL26_08170 CAZ10_01240 L4V69_34505 pilN GNQ48_04065 DT376_01070 IPC1295_08190 Structure source: Experimental + AlphaFold UniProt G3XD30 UniProt Q51352
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Amino acids 198
Annotations 4
Features 8
PDB binders 0
Druggability 0.845

Overview

Basic information about this protein and its source genome.

Accession
PA5043
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5043 GUL26_08170 CAZ10_01240 L4V69_34505 pilN GNQ48_04065 DT376_01070 IPC1295_08190
Status
annotated
Amino acids
198
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0043683 The assembly from its constituent parts of a type IV pilus. GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.845
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044096 A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.
  • GO:0043683 The assembly from its constituent parts of a type IV pilus.
  • GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
47 91 Coils Coil Coil
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
100 177 Pfam PF05137 Fimbrial assembly protein (PilN)
100 177 InterPro IPR007813 Type IV pilus inner membrane component PilN
40 198 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 188 PANTHER PTHR40278 DNA UTILIZATION PROTEIN HOFN
21 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5EOU
X-ray 2.40 Å A,B
6.1% 1-12
PDBe RCSB PDBj File
Viewing
AlphaFold PA5043
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.42 0.869
2 2.04 0.045