Protein profile

PA5048

nuclease

Genome: NC_002516.2

Gene: PA5048 Structure source: AlphaFold UniProt Q9HUD1
Export view
Amino acids 255
Annotations 2
Features 16
PDB binders 0
Druggability 0.92

Overview

Basic information about this protein and its source genome.

Accession
PA5048
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5048
Status
annotated
Amino acids
255
Structure source
AlphaFold
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.92
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
44 156 PANTHER PTHR12302 EBNA2 BINDING PROTEIN P100
22 156 SUPERFAMILY SSF50199 Staphylococcal nuclease
22 156 InterPro IPR035437 SNase-like, OB-fold superfamily
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
1 18 SignalP_EUK SignalP-noTM SignalP-noTM
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
19 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
24 155 ProSiteProfiles PS50830 Thermonuclease domain profile.
24 155 InterPro IPR016071 Staphylococcal nuclease (SNase-like), OB-fold
24 155 SMART SM00318 SNASE_2
47 154 Pfam PF00565 Staphylococcal nuclease homologue
47 154 InterPro IPR016071 Staphylococcal nuclease (SNase-like), OB-fold
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
22 157 Gene3D G3DSA:2.40.50.90 -
22 157 InterPro IPR035437 SNase-like, OB-fold superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5048
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.92
3 0.501
6 0.241