Protein profile

PA5052

hypothetical protein

Genome: NC_002516.2

Gene: PA5052 Structure source: AlphaFold UniProt Q9HUC7
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Amino acids 231
Annotations 2
Features 15
PDB binders 0
Druggability 0.588

Overview

Basic information about this protein and its source genome.

Accession
PA5052
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5052
Status
annotated
Amino acids
231
Structure source
AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.588
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
24 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
47 92 MobiDBLite mobidb-lite consensus disorder prediction
27 46 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
149 228 ProSiteProfiles PS51724 SPOR domain profile.
149 228 InterPro IPR007730 Sporulation-like domain
149 228 Gene3D G3DSA:3.30.70.1070 Sporulation related repeat
149 228 InterPro IPR036680 Sporulation-like domain superfamily
66 90 MobiDBLite mobidb-lite consensus disorder prediction
152 225 SUPERFAMILY SSF110997 Sporulation related repeat
152 225 InterPro IPR036680 Sporulation-like domain superfamily
152 222 Pfam PF05036 SPOR domain
152 222 InterPro IPR007730 Sporulation-like domain
1 26 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
47 231 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 221 PANTHER PTHR34183 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5052
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.588
1 0.333