Protein profile

PA5056

poly(3-hydroxyalkanoic acid) synthase

Genome: NC_002516.2

Gene: PAERUG_P19_London_7_VIM_2_05_10_03116 phaC phaC1 phbC_1 CAZ10_01170 L4V69_34570 PA5056 Structure source: AlphaFold UniProt G3XCV5 UniProt Q51513
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Amino acids 559
Annotations 2
Features 10
PDB binders 0
Druggability 0.791

Overview

Basic information about this protein and its source genome.

Accession
PA5056
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PAERUG_P19_London_7_VIM_2_05_10_03116 phaC phaC1 phbC_1 CAZ10_01170 L4V69_34570 PA5056
Status
annotated
Amino acids
559
Structure source
AlphaFold
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0042619 The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.791
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0042619 The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
75 243 Pfam PF07167 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus
75 243 InterPro IPR010941 Poly-beta-hydroxybutyrate polymerase, N-terminal domain
194 486 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
194 486 InterPro IPR029058 Alpha/Beta hydrolase fold
1 559 NCBIfam TIGR01839 class II poly(R)-hydroxyalkanoic acid synthase
1 559 InterPro IPR011287 Poly(R)-hydroxyalkanoic acid synthase, class II
198 489 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
198 489 InterPro IPR029058 Alpha/Beta hydrolase fold
533 559 MobiDBLite mobidb-lite consensus disorder prediction
65 557 PANTHER PTHR36837 POLY(3-HYDROXYALKANOATE) POLYMERASE SUBUNIT PHAC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5056
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.791
24 0.259