Protein profile

PA5058

poly(3-hydroxyalkanoic acid) synthase

Genome: NC_002516.2

Gene: PA5058 phaC2 Structure source: AlphaFold UniProt G3XCZ9 UniProt Q51515

Export view

Amino acids 560

Annotations 2

Features 9

PDB binders 0

Druggability 0.731

Overview

Basic information about this protein and its source genome.

Accession: PA5058
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5058 phaC2
Status: annotated
Amino acids: 560
Structure source: AlphaFold

GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0042619 The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.731

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MREKQESGSVPVPAEFMSAQSAIVGLRGKDLLTTVRSLAVHGLRQPLHSARHLVAFGGQLGKVLLGDTLHQPNPQDARFQDPSWRLNPFYRRTLQAYLAWQKQLLAWIDESNLDCDDRARARFLVALLSDAVAPSNSLINPLALKELFNTGGISLLNGVRHLLEDLVHNGGMPSQVNKTAFEIGRNLATTQGAVVFRNEVLELIQYKPLGERQYAKPLLIVPPQINKYYIFDLSPEKSFVQYALKNNLQVFVISWRNPDAQHREWGLSTYVEALDQAIEVSREITGSRSVNLAGACAGGLTVAALLGHLQVRRQLRKVSSVTYLVSLLDSQMESPAMLFADEQTLESSKRRSYQHGVLDGRDMAKVFAWMRPNDLIWNYWVNNYLLGRQPPAFDILYWNNDNTRLPAAFHGELLDLFKHNPLTRPGALEVSGTAVDLGKVAIDSFHVAGITDHITPWDAVYRSALLLGGQRRFILSNSGHIQSILNPPGNPKACYFENDKLSSDPRAWYYDAKREEGSWWPVWLGWLQERSGELGNPDFNLGSAAHPPLEAAPGTYVHIR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
GO:0042619 The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
205	487	Gene3D	G3DSA:3.40.50.1820	alpha/beta hydrolase
205	487	InterPro	IPR029058	Alpha/Beta hydrolase fold
66	559	PANTHER	PTHR36837	POLY(3-HYDROXYALKANOATE) POLYMERASE SUBUNIT PHAC
201	492	SUPERFAMILY	SSF53474	alpha/beta-Hydrolases
201	492	InterPro	IPR029058	Alpha/Beta hydrolase fold
75	243	Pfam	PF07167	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus
75	243	InterPro	IPR010941	Poly-beta-hydroxybutyrate polymerase, N-terminal domain
1	560	NCBIfam	TIGR01839	class II poly(R)-hydroxyalkanoic acid synthase
1	560	InterPro	IPR011287	Poly(R)-hydroxyalkanoic acid synthase, class II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5058	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.731