Protein profile

PA5066

phosphoribosyl-AMP cyclohydrolase

Genome: NC_002516.2

Gene: PA5066 hisI Structure source: AlphaFold UniProt Q9HUB7
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Amino acids 134
Annotations 7
Features 10
PDB binders 0
Druggability 0.576

Overview

Basic information about this protein and its source genome.

Accession
PA5066
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5066 hisI
Status
annotated
Amino acids
134
Structure source
AlphaFold
EC
3.5.4.19
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000287 Binding to a magnesium (Mg) ion. GO:0004635 Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. GO:0004636 Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+. GO:0008270 Binding to a zinc ion (Zn). GO:0000105 The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.576
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0004635 Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.
  • GO:0004636 Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0000105 The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
4 110 PANTHER PTHR42945 HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN
1 95 FunFam G3DSA:3.10.20.810:FF:000001 Histidine biosynthesis bifunctional protein HisIE
4 108 Hamap MF_01021 Phosphoribosyl-AMP cyclohydrolase [hisI].
4 108 InterPro IPR026660 Phosphoribosyl-AMP cyclohydrolase
3 95 Gene3D G3DSA:3.10.20.810 -
3 95 InterPro IPR038019 Phosphoribosyl-AMP cyclohydrolase domain superfamily
30 104 Pfam PF01502 Phosphoribosyl-AMP cyclohydrolase
30 104 InterPro IPR002496 Phosphoribosyl-AMP cyclohydrolase domain
4 120 SUPERFAMILY SSF141734 HisI-like
4 120 InterPro IPR038019 Phosphoribosyl-AMP cyclohydrolase domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5066
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.576