Protein profile

PA5067

phosphoribosyl-ATP pyrophosphatase

Genome: NC_002516.2

Gene: hisE PA5067 Structure source: AlphaFold UniProt Q9HUB6
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Amino acids 111
Annotations 5
Features 10
PDB binders 0
Druggability 0.97

Overview

Basic information about this protein and its source genome.

Accession
PA5067
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
hisE PA5067
Status
annotated
Amino acids
111
Structure source
AlphaFold
EC
3.6.1.31
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004636 Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+. GO:0000105 The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.97
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0004636 Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+.
  • GO:0000105 The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
2 92 Hamap MF_01020 Phosphoribosyl-ATP pyrophosphatase [hisE].
2 92 InterPro IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase
5 92 NCBIfam TIGR03188 phosphoribosyl-ATP diphosphatase
5 92 InterPro IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase
3 96 SUPERFAMILY SSF101386 all-alpha NTP pyrophosphatases
5 92 CDD cd11534 NTP-PPase_HisIE_like
3 103 PANTHER PTHR42945 HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN
1 98 Gene3D G3DSA:1.10.287.1080 -
7 95 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase
7 95 InterPro IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5067
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.97