Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5068
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tatA PA5068
Status: annotated
Amino acids: 82
Structure source: AlphaFold

GO

GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. GO:0008320 Enables the transfer of a protein from one side of a membrane to the other. GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.
GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.
GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
1	81	Hamap	MF_00236	Sec-independent protein translocase protein TatA [tatA].
1	81	InterPro	IPR006312	Sec-independent protein translocase protein TatA/E
6	22	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	48	NCBIfam	TIGR01411	twin-arginine translocase TatA/TatE family subunit
4	48	InterPro	IPR006312	Sec-independent protein translocase protein TatA/E
2	53	Gene3D	G3DSA:1.20.5.3310	-
23	82	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
43	82	MobiDBLite	mobidb-lite	consensus disorder prediction
6	52	Pfam	PF02416	mttA/Hcf106 family
6	52	InterPro	IPR003369	Sec-independent protein translocase protein TatA/B/E
1	21	SignalP_EUK	SignalP-TM	SignalP-TM
1	77	PANTHER	PTHR42982	SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA
1	5	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	21	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA5068 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5068	AlphaFold	—	—	full sequence	—	Viewing