Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5069
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tatB PA5069
Status: annotated
Amino acids: 141
Structure source: AlphaFold

GO

GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. GO:0008320 Enables the transfer of a protein from one side of a membrane to the other. GO:0009977 Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane. GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.638

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MFGISFSELLLVGLVALLVLGPERLPGAARTAGLWIGRLKRSFNTIKQEVEREIGADEIRRQLHNEHILSMEREAQKLLAPLTGQNPPQETPPPAAESPAPSVPTPPPTSTPAVPPADAAAPPAVAASTPPSPPSETPRNP

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.
GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.
GO:0009977 Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane.
GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
126	141	MobiDBLite	mobidb-lite	consensus disorder prediction
9	20	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	50	Gene3D	G3DSA:1.20.5.3310	-
2	76	NCBIfam	TIGR01410	Sec-independent protein translocase protein TatB
2	76	InterPro	IPR018448	Sec-independent protein translocase protein TatB
1	122	PANTHER	PTHR33162	SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA, CHLOROPLASTIC
1	8	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	31	Phobius	SIGNAL_PEPTIDE	Signal peptide region
86	119	MobiDBLite	mobidb-lite	consensus disorder prediction
32	141	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	116	Hamap	MF_00237	Sec-independent protein translocase protein TatB [tatB].
1	116	InterPro	IPR018448	Sec-independent protein translocase protein TatB
4	49	Pfam	PF02416	mttA/Hcf106 family
4	49	InterPro	IPR003369	Sec-independent protein translocase protein TatA/B/E
40	58	PRINTS	PR01506	Bacterial sec-independent translocation TatB protein signature
21	40	PRINTS	PR01506	Bacterial sec-independent translocation TatB protein signature
1	21	PRINTS	PR01506	Bacterial sec-independent translocation TatB protein signature
67	141	MobiDBLite	mobidb-lite	consensus disorder prediction
1	21	SignalP_EUK	SignalP-noTM	SignalP-noTM
21	31	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5069	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.638

PA5069