Protein profile

PA5072

chemotaxis transducer

Genome: NC_002516.2

Gene: mcpK PA5072 Structure source: AlphaFold UniProt Q9HUB1
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Amino acids 647
Annotations 5
Features 41
PDB binders 0
Druggability 0.953

Overview

Basic information about this protein and its source genome.

Accession
PA5072
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
mcpK PA5072
Status
annotated
Amino acids
647
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.953
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
45 287 ProSiteProfiles PS51753 HBM domain profile.
45 287 InterPro IPR032255 Helical bimodular sensor domain
37 292 SMART SM01358 HBM_sequencesselection_2
37 292 InterPro IPR032255 Helical bimodular sensor domain
314 647 Gene3D G3DSA:1.10.287.950 -
20 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
314 647 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
18 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
312 367 Pfam PF00672 HAMP domain
312 367 InterPro IPR003660 HAMP domain
412 607 CDD cd11386 MCP_signal
292 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
79 99 Coils Coil Coil
453 473 Coils Coil Coil
418 438 Coils Coil Coil
130 248 Gene3D G3DSA:1.20.1440.210 -
385 646 SMART SM00283 MA_2
385 646 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
375 611 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
375 611 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
512 541 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
512 541 InterPro IPR004090 Chemotaxis methyl-accepting receptor
406 435 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
406 435 InterPro IPR004090 Chemotaxis methyl-accepting receptor
483 510 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
483 510 InterPro IPR004090 Chemotaxis methyl-accepting receptor
343 647 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
47 286 Pfam PF16591 Helical bimodular sensor domain
47 286 InterPro IPR032255 Helical bimodular sensor domain
41 291 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 646 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
429 613 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
429 613 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
314 370 ProSiteProfiles PS50885 HAMP domain profile.
314 370 InterPro IPR003660 HAMP domain
377 423 SMART SM00304 HAMP_11
377 423 InterPro IPR003660 HAMP domain
314 370 SMART SM00304 HAMP_11
293 312 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
313 647 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5072
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.953
7 0.269