Protein profile

PA5076

ABC transporter

Genome: NC_002516.2

Gene: PA5076 Structure source: AlphaFold UniProt Q9HUA7
Export view
Amino acids 266
Annotations 4
Features 21
PDB binders 2
Druggability 0.641

Overview

Basic information about this protein and its source genome.

Accession
PA5076
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5076
Status
annotated
Amino acids
266
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents. GO:0015276 Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.641
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents.
  • GO:0015276 Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
35 258 SMART SM00079 GluR_14
35 258 InterPro IPR001320 Ionotropic glutamate receptor, C-terminal
36 257 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3
36 257 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
122 217 Gene3D G3DSA:3.40.190.10 -
24 266 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
32 254 Gene3D G3DSA:3.40.190.10 -
35 256 CDD cd13629 PBP2_Dsm1740
1 258 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
58 71 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
58 71 InterPro IPR018313 Solute-binding protein family 3, conserved site
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
35 259 SMART SM00062 AABind_6
35 259 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
17 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
5 262 PANTHER PTHR35936 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5076
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.641

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ORN
3VVD
Q72JG5 132.2 Da LogP -0.86 TPSA 89.3 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CN
SLZ
3VV5
Q72JG5 164.2 Da LogP -0.91 TPSA 89.3 ✓ Ro5 ✓ Clean C(CSC[C@@H](C(=O)O)N)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.