Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5077
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: opgH mdoH PA5077
Status: annotated
Amino acids: 861
Structure source: AlphaFold

EC

2.4.1.-

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:1900727 The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.835

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

2.4.1.-

Gene Ontology (GO)

4

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
GO:1900727 The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records

Show feature table

Start	End	DB	Term	Name
683	705	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
628	682	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
249	431	Pfam	PF00535	Glycosyl transferase family 2
249	431	InterPro	IPR001173	Glycosyltransferase 2-like
515	543	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
72	748	Hamap	MF_01072	Glucans biosynthesis glucosyltransferase H [mdoH].
72	748	InterPro	IPR023725	Glucan biosynthesis glucosyltransferase H
1	141	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
595	605	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
191	220	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
67	823	PANTHER	PTHR43867	CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]
240	471	FunFam	G3DSA:3.90.550.10:FF:000047	Glucans biosynthesis glucosyltransferase H
570	594	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
705	861	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
247	533	SUPERFAMILY	SSF53448	Nucleotide-diphospho-sugar transferases
247	533	InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
247	500	CDD	cd04191	Glucan_BSP_MdoH
142	159	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
606	627	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
544	569	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
142	159	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
198	220	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
572	594	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
244	471	Gene3D	G3DSA:3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
244	471	InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
683	704	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
221	514	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
160	190	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
521	543	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
601	623	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5077	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.835

PA5077