Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5078
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5078 opgG
Status: annotated
Amino acids: 525
Structure source: AlphaFold

GO

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051274 The chemical reactions and pathways resulting in the formation of beta-glucans. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.629

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MIFRSVSNTDFRARVRTLLLAGSTALAFVAAPVWAFSIDDVASKAKDLAGDKYSAPTSNLPSEFSEMKFADYQQIRFINERAYWGKLKTPFKLSFYHQGMHFDTPVKINEVTATTVKPIKYDRTKFDFGSLKFDENATKDLGYAGFRVLYPINKADKQDEIATFLGASYFRVVGKGQVYGLSARGLAIDTALPSGEEFPRFREFWIERPKAQDKQLVIYALLDSPRATGAYRFVLRPGKDAVMDVQARVFLRDKVSKLGLAPLTSMYLFGSNQPSEQHNFRPELHDSSGLQIHAGNGEWLWRPLNNPKHLSVSTFSVENPKGFGLLQRGREFSRYEDLDDRYDLRPSAWIEPKGDWGKGTVELVEIPTPDETNDNIVAFWNPETQPEVGKPLDFAYRLHWTMDEDELHDPKSSWVKQTMRSVGDVKQKNLIRQQDGSTALVVDFEGPALKDLAPDAPVTTQVSTDSNAEVVENSLRYNPVLKGWRLTLRIKVKDPKKPVEMRAALVDEAQKPLSETWSYQLPADE

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0051274 The chemical reactions and pathways resulting in the formation of beta-glucans.
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
GO:0016051 The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
36	525	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35	408	FunFam	G3DSA:2.70.98.10:FF:000001	Glucans biosynthesis protein G
30	35	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	17	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	525	PIRSF	PIRSF006281	MdoG
1	525	InterPro	IPR014438	Glucan biosynthesis protein MdoG/MdoD
35	410	Gene3D	G3DSA:2.70.98.10	-
35	410	InterPro	IPR014718	Glycoside hydrolase-type carbohydrate-binding
18	525	PANTHER	PTHR30504	GLUCANS BIOSYNTHESIS PROTEIN
18	525	InterPro	IPR014438	Glucan biosynthesis protein MdoG/MdoD
411	524	SUPERFAMILY	SSF81296	E set domains
411	524	InterPro	IPR014756	Immunoglobulin E-set
1	37	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
36	407	SUPERFAMILY	SSF74650	Galactose mutarotase-like
36	407	InterPro	IPR011013	Galactose mutarotase-like domain superfamily
18	29	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
18	523	Hamap	MF_01069	Glucans biosynthesis protein G [mdoG].
18	523	InterPro	IPR023704	Glucan biosynthesis protein G
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
411	525	Gene3D	G3DSA:2.60.40.10	Immunoglobulins
411	525	InterPro	IPR013783	Immunoglobulin-like fold
1	35	Phobius	SIGNAL_PEPTIDE	Signal peptide region
36	520	Pfam	PF04349	Periplasmic glucan biosynthesis protein, MdoG
36	520	InterPro	IPR007444	Glucan biosynthesis, periplasmic, MdoG C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5078	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.629

PA5078