Protein profile

PA5084

oxidoreductase

Genome: NC_002516.2

Gene: dadA2 PA5084 Structure source: AlphaFold UniProt Q9HU99
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Amino acids 416
Annotations 7
Features 19
PDB binders 1
Druggability 0.832

Overview

Basic information about this protein and its source genome.

Accession
PA5084
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
dadA2 PA5084
Status
annotated
Amino acids
416
Structure source
AlphaFold
EC
1.4.99.-
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008718 Catalysis of the reaction: a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4+. GO:0055130 The chemical reactions and pathways resulting in the breakdown of D-alanine. GO:0019478 The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.832
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008718 Catalysis of the reaction: a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4+.
  • GO:0055130 The chemical reactions and pathways resulting in the breakdown of D-alanine.
  • GO:0019478 The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
5 54 Gene3D G3DSA:3.50.50.60 -
5 54 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
4 394 Pfam PF01266 FAD dependent oxidoreductase
4 394 InterPro IPR006076 FAD dependent oxidoreductase
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
137 356 Gene3D G3DSA:3.30.9.10 -
4 406 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
4 406 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
104 396 Gene3D G3DSA:3.50.50.60 -
104 396 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
267 357 SUPERFAMILY SSF54373 FAD-linked reductases, C-terminal domain
21 416 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 396 PANTHER PTHR13847 SARCOSINE DEHYDROGENASE-RELATED
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
3 408 Hamap MF_01202 D-amino acid dehydrogenase [dadA].
3 408 InterPro IPR023080 D-amino acid dehydrogenase DadA
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5084
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.832
10 0.265

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

44 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
B6X
6J39
X5IYZ1 248.3 Da LogP 2.62 TPSA 74.6 ✓ Ro5 ✓ Clean CCCCCC[C@H](CC(=O)O)SCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.