Protein profile

PA5091

N-formylglutamate amidohydrolase

Genome: NC_002516.2

Gene: PA5091 hutG Structure source: AlphaFold UniProt Q9HU92
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Amino acids 266
Annotations 5
Features 7
PDB binders 0
Druggability 0.686

Overview

Basic information about this protein and its source genome.

Accession
PA5091
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5091 hutG
Status
annotated
Amino acids
266
Structure source
AlphaFold
EC
3.5.1.68
GO
GO:0050129 Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate. GO:0006548 The chemical reactions and pathways resulting in the breakdown of L-histidine. GO:0019556 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. GO:0019557 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.686
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDEVLSFKRGRVPLLISMPHPGTRLTPAVDAGLVEEARALTDTDWHIPRLYDFAEELGASTLAAHYSRYVVDLNRPSDDKPLYSTATTGLYPDTLFDGRPLYREGMAPSAEERMRYLAEVWTPYHRTIAEELARLKAEFGYALLWDAHSIRSHVPHLFDGRLPDFNLGTNAGASCDPALAARLEAVCAAAEGYSHVLNGRFKGGHITRHYGQPEQHVHAVQLELAQCTYMDEQAPFAYRADLAEATRAVIRELLESLLAWGRERYA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0050129 Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate.
  • GO:0006548 The chemical reactions and pathways resulting in the breakdown of L-histidine.
  • GO:0019556 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide.
  • GO:0019557 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
13 230 Pfam PF05013 N-formylglutamate amidohydrolase
13 230 InterPro IPR007709 N-formylglutamate amidohydrolase
2 260 Gene3D G3DSA:3.40.630.40 -
2 260 FunFam G3DSA:3.40.630.40:FF:000014 N-formylglutamate amidohydrolase
4 262 NCBIfam TIGR02017 N-formylglutamate deformylase
4 262 InterPro IPR010247 N-formylglutamate deformylase
5 263 SUPERFAMILY SSF53187 Zn-dependent exopeptidases

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5091
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.686
1 0.627