Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5105
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5105 hutC
Status: annotated
Amino acids: 250
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0019556 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. GO:0019557 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0019556 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide.
GO:0019557 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formate.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006547 OBSOLETE. The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
73	248	SUPERFAMILY	SSF64288	Chorismate lyase-like
73	248	InterPro	IPR028978	Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain superfamily
20	88	ProSiteProfiles	PS50949	GntR-type HTH domain profile.
20	88	InterPro	IPR000524	Transcription regulator HTH, GntR
19	248	PANTHER	PTHR44846	MANNOSYL-D-GLYCERATE TRANSPORT/METABOLISM SYSTEM REPRESSOR MNGR-RELATED
15	90	FunFam	G3DSA:1.10.10.10:FF:000079	GntR family transcriptional regulator
106	243	SMART	SM00866	UTRA_2
106	243	InterPro	IPR011663	UbiC transcription regulator-associated
104	239	Gene3D	G3DSA:3.40.1410.10	-
104	239	InterPro	IPR028978	Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain superfamily
21	249	NCBIfam	TIGR02018	histidine utilization repressor
21	249	InterPro	IPR010248	Histidine utilization repressor
26	85	SMART	SM00345	gntr3
26	85	InterPro	IPR000524	Transcription regulator HTH, GntR
22	85	Pfam	PF00392	Bacterial regulatory proteins, gntR family
22	85	InterPro	IPR000524	Transcription regulator HTH, GntR
17	95	Gene3D	G3DSA:1.10.10.10	-
17	95	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
104	239	FunFam	G3DSA:3.40.1410.10:FF:000004	Histidine utilization repressor
21	86	CDD	cd07377	WHTH_GntR
21	86	InterPro	IPR000524	Transcription regulator HTH, GntR
106	243	Pfam	PF07702	UTRA domain
20	89	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
20	89	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
45	59	PRINTS	PR00035	GntR bacterial regulatory protein HTH signature
45	59	InterPro	IPR000524	Transcription regulator HTH, GntR
59	75	PRINTS	PR00035	GntR bacterial regulatory protein HTH signature
59	75	InterPro	IPR000524	Transcription regulator HTH, GntR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA5105 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5105	AlphaFold	—	—	full sequence	—	Viewing

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
FLC	3CNV	A0A0H3LYW6	189.1 Da LogP -5.25 TPSA 140.6	✓ Ro5	✓ Clean	`C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.