Protein profile

PA5114

hypothetical protein

Genome: NC_002516.2

Gene: PA5114 Structure source: AlphaFold UniProt Q9HU70
Export view
Amino acids 1201
Annotations 0
Features 116
PDB binders 0
Druggability 0.903

Overview

Basic information about this protein and its source genome.

Accession
PA5114
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5114
Status
annotated
Amino acids
1201
Structure source
AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.903
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

116 records
Show feature table
Start End DB Term Name
303 313 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
490 494 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
747 769 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
684 694 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
784 802 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
901 923 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
413 435 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
548 565 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1106 1127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
878 897 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
748 769 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 59 Coils Coil Coil
811 833 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
696 718 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
742 747 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
770 780 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1003 1024 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
439 456 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
236 257 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
898 908 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
369 386 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
290 309 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1168 1185 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
878 897 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
341 360 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
801 811 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
630 649 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
812 834 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
723 740 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
364 386 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 SignalP_EUK SignalP-TM SignalP-TM
78 163 MobiDBLite mobidb-lite consensus disorder prediction
608 625 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
333 338 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
512 517 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
835 853 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
585 604 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1168 1187 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
441 458 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
566 584 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
120 137 MobiDBLite mobidb-lite consensus disorder prediction
543 565 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
237 259 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1025 1035 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
992 1002 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
182 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
928 933 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
719 723 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
470 489 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1095 1105 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
695 718 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
258 268 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
537 547 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
724 741 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
626 629 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
518 536 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
495 511 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
231 235 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
263 285 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
469 491 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
314 336 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
603 607 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
959 969 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1036 1054 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
608 625 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1186 1201 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
178 533 Pfam PF10101 Predicted membrane protein (DUF2339)
178 533 InterPro IPR019286 Protein of unknown function DUF2339, transmembrane
663 1188 Pfam PF10101 Predicted membrane protein (DUF2339)
663 1188 InterPro IPR019286 Protein of unknown function DUF2339, transmembrane
213 230 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
339 357 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
872 877 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
387 412 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
436 440 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
358 368 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1139 1156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1128 1138 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
935 957 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
967 989 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
213 230 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
202 212 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1076 1095 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 181 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
4 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
662 684 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
630 652 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1157 1167 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
854 871 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1075 1094 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
585 602 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1055 1074 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
269 302 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
519 538 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
934 958 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
314 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
781 800 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
650 660 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
28 638 PANTHER PTHR38434 BLL2549 PROTEIN
28 638 InterPro IPR019286 Protein of unknown function DUF2339, transmembrane
1110 1132 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
970 991 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
853 871 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1033 1055 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
459 469 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1001 1018 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
176 198 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
413 435 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
495 512 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1139 1158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
909 927 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
661 683 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5114
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.903
19 0.545
20 0.296
2 0.206