Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5133
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5133
Status: annotated
Amino acids: 428
Structure source: AlphaFold

GO

GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0000920 The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.795

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0000920 The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
20	428	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	19	Phobius	SIGNAL_PEPTIDE	Signal peptide region
229	267	Coils	Coil	Coil
1	19	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
327	420	Pfam	PF01551	Peptidase family M23
327	420	InterPro	IPR016047	Peptidase M23
1	3	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
243	260	MobiDBLite	mobidb-lite	consensus disorder prediction
1	19	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
239	424	SUPERFAMILY	SSF51261	Duplicated hybrid motif
239	424	InterPro	IPR011055	Duplicated hybrid motif
165	424	PANTHER	PTHR21666	PEPTIDASE-RELATED
290	425	Gene3D	G3DSA:2.70.70.10	Glucose Permease (Domain IIA)
290	425	InterPro	IPR011055	Duplicated hybrid motif
328	411	CDD	cd12797	M23_peptidase
177	219	MobiDBLite	mobidb-lite	consensus disorder prediction
290	426	FunFam	G3DSA:2.70.70.10:FF:000003	Murein hydrolase activator EnvC
44	270	Gene3D	G3DSA:6.10.250.3150	-
243	286	MobiDBLite	mobidb-lite	consensus disorder prediction
155	175	Coils	Coil	Coil
22	105	Coils	Coil	Coil
15	19	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
179	219	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5133	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.795
4				0.793
2				0.324
11				0.262

PA5133