Protein profile

PA5149

hypothetical protein

Genome: NC_002516.2

Gene: PA5149 Structure source: AlphaFold UniProt Q9HU35
Export view
Amino acids 360
Annotations 4
Features 9
PDB binders 6
Druggability 0.592

Overview

Basic information about this protein and its source genome.

Accession
PA5149
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5149
Status
annotated
Amino acids
360
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0102497 Catalysis of the reaction: scyllo-inositol + NADP = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+. GO:0017000 The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.508
Human E-value
8.4e-06
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.592
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0102497 Catalysis of the reaction: scyllo-inositol + NADP = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+.
  • GO:0017000 The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
143 350 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain
143 350 InterPro IPR004104 Gfo/Idh/MocA-like oxidoreductase, C-terminal
11 320 Gene3D G3DSA:3.40.50.720 -
10 205 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
10 205 InterPro IPR036291 NAD(P)-binding domain superfamily
11 124 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold
11 124 InterPro IPR000683 Gfo/Idh/MocA-like oxidoreductase, N-terminal
9 349 PANTHER PTHR43708 CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)
134 330 Gene3D G3DSA:3.30.360.10 Dihydrodipicolinate Reductase; domain 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5149
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.592
10 0.225

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BLA
5B3V
P72782 582.7 Da LogP 4.81 TPSA 160.9 1 viol. ✓ Clean Cc1c(c([nH]c1\C=C/2\C(=C(C(=O)N2)C=C)C)\C=C/3\C…
CJX
6JW7
Q6L737 485.5 Da LogP -7.26 TPSA 276.8 2 viol. ✓ Clean C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C…
CK0
6JW8
Q6L737 484.5 Da LogP -7.29 TPSA 282.6 2 viol. ✓ Clean C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C…
HP7
3Q2K
Q79H45 621.3 Da LogP -4.56 TPSA 322.9 3 viol. ✓ Clean CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[P@@]…
SIN
1H6C
Q07982 118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O
TLO
3RC1
B3TMR8 478.3 Da LogP 0.81 TPSA 186.6 ✓ Ro5 ✓ Clean CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[P@]…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.