Protein profile

PA5157

transcriptional regulator

Genome: NC_002516.2

Gene: PA5157 Structure source: AlphaFold UniProt Q9HU27
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Amino acids 156
Annotations 4
Features 21
PDB binders 3

Overview

Basic information about this protein and its source genome.

Accession
PA5157
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5157
Status
annotated
Amino acids
156
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
14 145 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
14 145 InterPro IPR036390 Winged helix DNA-binding domain superfamily
32 132 SMART SM00347 marrlong4
32 132 InterPro IPR000835 MarR-type HTH domain
71 105 ProSitePatterns PS01117 MarR-type HTH domain signature.
71 105 InterPro IPR023187 Transcriptional regulator MarR-type, conserved site
39 96 Pfam PF01047 MarR family
39 96 InterPro IPR000835 MarR-type HTH domain
2 146 Gene3D G3DSA:1.10.10.10 -
2 146 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
22 143 PANTHER PTHR42756 TRANSCRIPTIONAL REGULATOR, MARR
56 72 PRINTS PR00598 Bacterial regulatory protein MarR family signature
56 72 InterPro IPR000835 MarR-type HTH domain
92 108 PRINTS PR00598 Bacterial regulatory protein MarR family signature
92 108 InterPro IPR000835 MarR-type HTH domain
122 142 PRINTS PR00598 Bacterial regulatory protein MarR family signature
122 142 InterPro IPR000835 MarR-type HTH domain
73 88 PRINTS PR00598 Bacterial regulatory protein MarR family signature
73 88 InterPro IPR000835 MarR-type HTH domain
12 144 ProSiteProfiles PS50995 MarR-type HTH domain profile.
12 144 InterPro IPR000835 MarR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model PA5157 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5157
AlphaFold — — full sequence — Viewing

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
IAC
7KUA
B0FXI7 175.2 Da LogP 1.79 TPSA 53.1 ✓ Ro5 ✓ Clean c1ccc2c(c1)c(c[nH]2)CC(=O)O
SAL
3BPX
O26413 138.1 Da LogP 1.09 TPSA 57.5 ✓ Ro5 ✓ Clean c1ccc(c(c1)C(=O)O)O
WCA
6C28
Q6N8V9 913.7 Da LogP 0.08 TPSA 383.9 3 viol. ✓ Clean CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.