Protein profile

PA5167

C4-dicarboxylate-binding protein

Genome: NC_002516.2

Gene: dctP PA5167 Structure source: Experimental + AlphaFold UniProt Q9HU18
Export view
Amino acids 331
Annotations 3
Features 20
PDB binders 2
Druggability 0.302

Overview

Basic information about this protein and its source genome.

Accession
PA5167
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
dctP PA5167
Status
annotated
Amino acids
331
Structure source
Experimental + AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015740 The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.302
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0015740 The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
24 331 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
26 328 FunFam G3DSA:3.40.190.170:FF:000001 TRAP dicarboxylate transporter, DctP subunit
27 331 Gene3D G3DSA:3.40.190.170 -
27 331 InterPro IPR038404 TRAP transporter solute receptor DctP superfamily
31 313 Pfam PF03480 Bacterial extracellular solute-binding protein, family 7
31 313 InterPro IPR018389 TRAP transporter solute receptor DctP
3 328 PANTHER PTHR33376 -
3 328 InterPro IPR018389 TRAP transporter solute receptor DctP
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
28 325 CDD cd13674 PBP2_TRAP_SBP_like_1
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
30 301 NCBIfam NF037995 TRAP transporter substrate-binding protein DctP
31 272 NCBIfam TIGR00787 DctP family TRAP transporter solute-binding subunit
31 272 InterPro IPR004682 TRAP transporter solute receptor, DctP family
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 330 PIRSF PIRSF006470 DctB
1 330 InterPro IPR004682 TRAP transporter solute receptor, DctP family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9DY3
X-ray 1.30 Å A
93.4% 23-331
PDBe RCSB PDBj File
Viewing
PDB 9DSY
X-ray 1.35 Å A
93.4% 23-331
PDBe RCSB PDBj File
Loaded
AlphaFold PA5167
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.302

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.19 0.374
2 6.25 0.313
3 2.53 0.071

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

39 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
LMR
4O7M
A3QCW5 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@@H](C(=O)O)O)C(=O)O
SIN
4OA4
A3QCW5 118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.