Protein profile

PA5171

arginine deiminase

Genome: NC_002516.2

Gene: arcA PA5171 Structure source: Experimental + AlphaFold UniProt P13981
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Amino acids 418
Annotations 5
Features 23
PDB binders 1
Druggability 0.773

Overview

Basic information about this protein and its source genome.

Accession
PA5171
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
arcA PA5171
Status
annotated
Amino acids
418
Structure source
Experimental + AlphaFold
EC
3.5.3.6
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016990 Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH4+. GO:0019546 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase. GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.773
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016990 Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH4+.
  • GO:0019546 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase.
  • GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
7 416 SUPERFAMILY SSF55909 Pentein
352 369 PRINTS PR01466 Bacterial arginine deiminase signature
352 369 InterPro IPR003876 Arginine deiminase
6 26 PRINTS PR01466 Bacterial arginine deiminase signature
6 26 InterPro IPR003876 Arginine deiminase
157 175 PRINTS PR01466 Bacterial arginine deiminase signature
157 175 InterPro IPR003876 Arginine deiminase
372 386 PRINTS PR01466 Bacterial arginine deiminase signature
372 386 InterPro IPR003876 Arginine deiminase
185 200 PRINTS PR01466 Bacterial arginine deiminase signature
185 200 InterPro IPR003876 Arginine deiminase
395 413 PRINTS PR01466 Bacterial arginine deiminase signature
395 413 InterPro IPR003876 Arginine deiminase
10 413 Gene3D G3DSA:3.75.10.10 -
3 415 PANTHER PTHR47271 ARGININE DEIMINASE
38 413 Pfam PF02274 Arginine deiminase
10 416 NCBIfam TIGR01078 arginine deiminase
10 416 InterPro IPR003876 Arginine deiminase
1 416 PIRSF PIRSF006356 ADI
1 416 InterPro IPR003876 Arginine deiminase
5 416 Hamap MF_00242 Arginine deiminase [arcA].
5 416 InterPro IPR003876 Arginine deiminase
72 157 Gene3D G3DSA:1.10.3930.10 Arginine deiminase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2A9G
X-ray 2.30 Å A,B,C,D
100.0% 1-418
PDBe RCSB PDBj File
Viewing
PDB 2AAF
X-ray 2.30 Å A,B,C,D
100.0% 1-418
PDBe RCSB PDBj File
Loaded
PDB 2ACI
X-ray 2.50 Å A,B,C,D
100.0% 1-418
PDBe RCSB PDBj File
Loaded
PDB 2ABR
X-ray 2.90 Å A,B,C,D
100.0% 1-418
PDBe RCSB PDBj File
Loaded
PDB 1RXX
X-ray 2.45 Å A,B,C,D
99.8% 2-418
PDBe RCSB PDBj File
Loaded
AlphaFold PA5171
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
CIR
1LXY
P23793 175.2 Da LogP -1.15 TPSA 118.4 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CNC(=O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.