Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5180
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5180 fdhD
Status: annotated
Amino acids: 279
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016783 Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0006777 The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.52

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
GO:0016783 Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
GO:0006777 The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
41	273	Pfam	PF02634	FdhD/NarQ family
41	273	InterPro	IPR003786	Sulfur carrier protein FdhD
36	273	SUPERFAMILY	SSF53927	Cytidine deaminase-like
36	273	InterPro	IPR016193	Cytidine deaminase-like
38	262	NCBIfam	TIGR00129	formate dehydrogenase accessory sulfurtransferase FdhD
38	262	InterPro	IPR003786	Sulfur carrier protein FdhD
133	278	Gene3D	G3DSA:3.40.140.10	Cytidine Deaminase, domain 2
17	278	Hamap	MF_00187	Sulfur carrier protein FdhD [fdhD].
17	278	InterPro	IPR003786	Sulfur carrier protein FdhD
42	128	Gene3D	G3DSA:3.10.20.10	-
23	274	PANTHER	PTHR30592	FORMATE DEHYDROGENASE
23	274	InterPro	IPR003786	Sulfur carrier protein FdhD
8	279	PIRSF	PIRSF015626	FdhD
8	279	InterPro	IPR003786	Sulfur carrier protein FdhD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5180	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.52

PA5180