Protein profile

PA5185

hypothetical protein

Genome: NC_002516.2

Gene: PA5185 Structure source: Experimental + AlphaFold UniProt Q9HU04
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Amino acids 147
Annotations 1
Features 8
PDB binders 0
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
PA5185
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5185
Status
annotated
Amino acids
147
Structure source
Experimental + AlphaFold
GO
GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 147 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
9 142 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
9 142 InterPro IPR029069 HotDog domain superfamily
1 147 FunFam G3DSA:3.10.129.10:FF:000147 Acyl-CoA thioesterase
1 142 PANTHER PTHR31793 4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER
14 121 CDD cd00586 4HBT
28 111 Pfam PF03061 Thioesterase superfamily
28 111 InterPro IPR006683 Thioesterase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2O5U
X-ray 1.91 Å A,B,C
100.0% 1-147
PDBe RCSB PDBj File
Viewing
PDB 2AV9
X-ray 2.40 Å A,B,C,D,E,F,G,H,I,J,K,L
100.0% 1-147
PDBe RCSB PDBj File
Loaded
PDB 2O6T
X-ray 2.55 Å A,C,E,G,I,K
100.0% 1-147
PDBe RCSB PDBj File
Loaded
PDB 2O6U
X-ray 3.01 Å A,B
100.0% 1-147
PDBe RCSB PDBj File
Loaded
PDB 2O6B
X-ray 3.21 Å A,B
100.0% 1-147
PDBe RCSB PDBj File
Loaded
AlphaFold PA5185
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.87
1 0.713
3 0.328

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.62 0.076