Protein profile

PA5193

heat shock protein 33

Genome: NC_002516.2

Gene: yrfI Structure source: ColabFold
Export view
Amino acids 297
Annotations 3
Features 20
PDB binders 0
Druggability 0.454

Overview

Basic information about this protein and its source genome.

Accession
PA5193
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
yrfI
Status
annotated
Amino acids
297
Structure source
ColabFold
GO
GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.454
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0051082 Binding to an unfolded protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
3 288 PANTHER PTHR30111 33 KDA CHAPERONIN
3 288 InterPro IPR000397 Heat shock protein Hsp33
180 228 Gene3D G3DSA:1.10.287.480 helix hairpin bin
180 228 InterPro IPR023212 Heat shock protein Hsp33, helix hairpin bin domain superfamily
1 287 PIRSF PIRSF005261 HSP33
1 287 InterPro IPR000397 Heat shock protein Hsp33
5 276 Pfam PF01430 Hsp33 protein
5 276 InterPro IPR000397 Heat shock protein Hsp33
4 234 SUPERFAMILY SSF64397 Hsp33 domain
4 234 InterPro IPR016153 Heat shock protein Hsp33, N-terminal
226 285 SUPERFAMILY SSF118352 HSP33 redox switch-like
226 285 InterPro IPR016154 Heat shock protein Hsp33, C-terminal
4 287 Hamap MF_00117 33 kDa chaperonin [hslO].
4 287 InterPro IPR000397 Heat shock protein Hsp33
8 276 CDD cd00498 Hsp33
8 276 InterPro IPR000397 Heat shock protein Hsp33
229 287 Gene3D G3DSA:3.90.1280.10 -
229 287 InterPro IPR016154 Heat shock protein Hsp33, C-terminal
1 173 Gene3D G3DSA:3.55.30.10 Hsp33 domain
1 173 InterPro IPR016153 Heat shock protein Hsp33, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA5193
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.454