Protein profile

PA5201

hypothetical protein

Genome: NC_002516.2

Gene: PA5201 Structure source: Experimental + AlphaFold UniProt Q9HTY8
Export view
Amino acids 779
Annotations 6
Features 41
PDB binders 1
Druggability 0.538

Overview

Basic information about this protein and its source genome.

Accession
PA5201
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5201
Status
annotated
Amino acids
779
Structure source
Experimental + AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.349
Human E-value
4.49e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.538
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
328 455 FunFam G3DSA:3.30.420.140:FF:000001 RNA-binding transcriptional accessory protein
1 114 Gene3D G3DSA:1.10.10.650 -
1 114 InterPro IPR023319 Tex-like protein, HTH domain superfamily
328 455 Gene3D G3DSA:3.30.420.140 -
328 455 InterPro IPR037027 YqgF/RNase H-like domain superfamily
495 559 Pfam PF12836 Helix-hairpin-helix motif
115 502 Gene3D G3DSA:1.10.3500.10 -
115 502 InterPro IPR023323 Tex-like domain superfamily
565 634 Pfam PF17674 HHH domain
565 634 InterPro IPR041692 HHH domain 9
329 428 SMART SM00732 rnase_8s
329 428 InterPro IPR006641 YqgF/RNase H-like domain
653 724 SMART SM00316 S1_6
653 724 InterPro IPR022967 RNA-binding domain, S1
1 114 FunFam G3DSA:1.10.10.650:FF:000001 S1 RNA-binding domain 1
325 473 SUPERFAMILY SSF53098 Ribonuclease H-like
325 473 InterPro IPR012337 Ribonuclease H-like superfamily
638 728 FunFam G3DSA:2.40.50.140:FF:000051 RNA-binding transcriptional accessory protein
503 634 FunFam G3DSA:1.10.150.310:FF:000001 RNA-binding transcriptional accessory protein
720 779 MobiDBLite mobidb-lite consensus disorder prediction
653 724 Pfam PF00575 S1 RNA binding domain
653 724 InterPro IPR003029 S1 domain
635 730 Gene3D G3DSA:2.40.50.140 -
635 730 InterPro IPR012340 Nucleic acid-binding, OB-fold
564 636 SUPERFAMILY SSF47781 RuvA domain 2-like
564 636 InterPro IPR010994 RuvA domain 2-like
642 729 SUPERFAMILY SSF50249 Nucleic acid-binding proteins
642 729 InterPro IPR012340 Nucleic acid-binding, OB-fold
474 560 SUPERFAMILY SSF47781 RuvA domain 2-like
474 560 InterPro IPR010994 RuvA domain 2-like
503 634 Gene3D G3DSA:1.10.150.310 -
330 455 Pfam PF16921 Tex protein YqgF-like domain
330 455 InterPro IPR032639 Tex protein, YqgF-like domain
655 724 ProSiteProfiles PS50126 S1 domain profile.
655 724 InterPro IPR003029 S1 domain
19 197 Pfam PF09371 Tex-like protein N-terminal domain
19 197 InterPro IPR018974 Tex-like protein, N-terminal
4 324 SUPERFAMILY SSF158832 Tex N-terminal region-like
655 722 CDD cd05685 S1_Tex
655 722 InterPro IPR044146 Tex, S1 domain
43 739 PANTHER PTHR10724 30S RIBOSOMAL PROTEIN S1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3BZC
X-ray 2.27 Å A
100.0% 1-779
PDBe RCSB PDBj File
Viewing
PDB 3BZK
X-ray 2.30 Å A
100.0% 1-779
PDBe RCSB PDBj File
Loaded
PDB 2OCE
X-ray 3.10 Å A
99.9% 2-779
PDBe RCSB PDBj File
Loaded
AlphaFold PA5201
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.538

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.07 0.164
2 2.17 0.051
3 1.98 0.042
4 1.62 0.026
5 1.19 0.01

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

39 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
VGL
4NNI
P9WH43 124.1 Da LogP 0.17 TPSA 63.1 ✓ Ro5 ✓ Clean c1cnc(cn1)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.