Protein profile

PA5216

iron ABC transporter substrate-binding protein

Genome: NC_002516.2

Gene: PA5216 Structure source: AlphaFold UniProt Q9HTX4
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Amino acids 539
Annotations 3
Features 56
PDB binders 0
Druggability 0.91

Overview

Basic information about this protein and its source genome.

Accession
PA5216
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5216
Status
annotated
Amino acids
539
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.91
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

56 records
Show feature table
Start End DB Term Name
133 155 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 253 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
68 253 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
51 252 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
51 252 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
228 252 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 53 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
54 75 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
284 306 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
476 510 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
531 539 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
323 531 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
323 531 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
386 404 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
453 475 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
193 215 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
351 361 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
51 230 CDD cd06261 TM_PBP2
51 230 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
404 426 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
328 350 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
156 191 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 531 PANTHER PTHR30183 MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB
217 227 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
362 385 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
114 132 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
309 327 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9 262 FunFam G3DSA:1.10.3720.10:FF:000088 Iron(III) ABC transporter, permease protein
405 428 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
87 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
280 531 SUPERFAMILY SSF161098 MetI-like
280 531 InterPro IPR035906 MetI-like superfamily
192 216 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
281 536 FunFam G3DSA:1.10.3720.10:FF:000092 Iron ABC transporter permease
8 252 SUPERFAMILY SSF161098 MetI-like
8 252 InterPro IPR035906 MetI-like superfamily
76 86 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
511 530 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
133 155 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
360 382 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
282 308 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
452 474 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
253 281 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
508 530 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 257 Gene3D G3DSA:1.10.3720.10 -
10 257 InterPro IPR035906 MetI-like superfamily
281 536 Gene3D G3DSA:1.10.3720.10 -
281 536 InterPro IPR035906 MetI-like superfamily
230 252 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
91 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
326 348 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
429 452 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56 78 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5216
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.91
1 0.844
9 0.59