Amino acids
394
Annotations
5
Features
24
PDB binders
0
Druggability
0.857
Overview
Basic information about this protein and its source genome.
- Accession
- PA5223
- Gene
- ubiH PA5223
- Status
- annotated
- Amino acids
- 394
- Structure source
- AlphaFold
GO
GO:0008681 Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+.
GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 31.548
- Human E-value
- 5.05e-17
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Unknown
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.857
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
5 GO
Gene Ontology (GO)
5- GO:0008681 Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+.
- GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
- GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
- GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
- GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
Sequence Features
Domain/signature hits from InterPro and related databases.
24 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 4 | 317 | Pfam | PF01494 | FAD binding domain |
| 4 | 317 | InterPro | IPR002938 | FAD-binding domain |
| 257 | 394 | Gene3D | G3DSA:3.50.50.60 | - |
| 257 | 394 | InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| 3 | 210 | Gene3D | G3DSA:3.50.50.60 | - |
| 3 | 210 | InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| 6 | 388 | NCBIfam | TIGR01988 | ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family |
| 6 | 388 | InterPro | IPR010971 | Ubiquinone biosynthesis hydroxylase UbiH/COQ6 |
| 296 | 312 | PRINTS | PR00420 | Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature |
| 5 | 27 | PRINTS | PR00420 | Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature |
| 281 | 296 | PRINTS | PR00420 | Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature |
| 157 | 172 | PRINTS | PR00420 | Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature |
| 22 | 394 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 5 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 3 | 216 | FunFam | G3DSA:3.50.50.60:FF:000123 | 2-octaprenyl-6-methoxyphenyl hydroxylase |
| 17 | 21 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 6 | 16 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 1 | 21 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 3 | 388 | PANTHER | PTHR43876 | UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL |
| 5 | 388 | NCBIfam | TIGR01984 | 2-octaprenyl-6-methoxyphenyl hydroxylase |
| 5 | 388 | InterPro | IPR011295 | 2-polyprenyl-6-methoxyphenol 4-hydroxylase |
| 4 | 383 | SUPERFAMILY | SSF51905 | FAD/NAD(P)-binding domain |
| 4 | 383 | InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| 7 | 26 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA5223
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.335 | ||||||
| 1 | 0.237 |