Protein profile

PA5227

hypothetical protein

Genome: NC_002516.2

Gene: zapA PA5227 Structure source: Experimental + AlphaFold UniProt Q9HTW3
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Amino acids 104
Annotations 6
Features 11
PDB binders 0
Druggability 0.583

Overview

Basic information about this protein and its source genome.

Accession
PA5227
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
zapA PA5227
Status
annotated
Amino acids
104
Structure source
Experimental + AlphaFold
GO
GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. GO:0000921 The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.583
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
  • GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
  • GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.
  • GO:0000921 The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
7 96 SUPERFAMILY SSF102829 Cell division protein ZapA-like
7 96 InterPro IPR036192 Cell division protein ZapA-like superfamily
49 104 Gene3D G3DSA:1.20.5.50 -
70 90 Coils Coil Coil
1 48 Gene3D G3DSA:3.30.160.880 -
1 48 InterPro IPR042233 Cell division protein ZapA, N-terminal
1 97 PANTHER PTHR34981 CELL DIVISION PROTEIN ZAPA
1 97 InterPro IPR007838 Cell division protein ZapA-like
1 48 FunFam G3DSA:3.30.160.880:FF:000002 Cell division protein ZapA
8 90 Pfam PF05164 Cell division protein ZapA
8 90 InterPro IPR007838 Cell division protein ZapA-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1T3U
X-ray 2.50 Å A,B,C,D
100.0% 1-104
PDBe RCSB PDBj File
Viewing
PDB 1W2E
X-ray 2.80 Å A,B
100.0% 1-104
PDBe RCSB PDBj File
Loaded
AlphaFold PA5227
AlphaFold — — full sequence — Loaded
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