Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA5230
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5230
Status: annotated
Amino acids: 374
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359 Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.742

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MRSLANIFNLGIKEFRSLGRDYAMLALIVWAFTLGVYSSATGIPETLHHAPIAVVDEDRSQLSSRIVNAFQPPYFRPPEMIGHAEMDRGMDVGLYTFTLDIPPDFQRDVLAGRKPSIQVNVDATQTGQAFSGAGYIQNIVATEVREFVSRYRAEPSMPAQIEVRMEFNPNLTQAWFGGVMEVINQITMLSIILTGAALIREREHGTVEHLLVMPLSAFEIMMAKVWSMGLVVLVAAGLSLQWVVRGWLDVPISGSVGLFLLGAGLHLFATTSMGIFLGTVARSMPQLGLLTILVLLPLNILSGGTTPRESMPELVQNIMLAAPTTHFVSLAQAILFRGAGFDIVWPQFAGIVVIGSAFFFGALWRFRRTISQMA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0140359 Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
287	305	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
365	374	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
220	244	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
174	199	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
256	280	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
27	363	Pfam	PF12698	ABC-2 family transporter protein
27	363	InterPro	IPR013525	ABC-2 type transporter, transmembrane domain
41	173	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
287	306	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
343	364	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
344	366	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
177	199	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
133	369	ProSiteProfiles	PS51012	ABC transporter integral membrane type-2 domain profile.
133	369	InterPro	IPR047817	ABC-2 type transporter, transmembrane domain, bacterial-type
1	20	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
245	255	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21	43	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	40	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
226	248	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
6	369	PANTHER	PTHR30294	MEMBRANE COMPONENT OF ABC TRANSPORTER YHHJ-RELATED
258	280	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
306	342	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
200	219	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
281	286	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41	174	Gene3D	G3DSA:3.40.1710.10	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5230	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.742
2				0.478
7				0.413
12				0.33

PA5230