Protein profile

PA5242

polyphosphate kinase

Genome: NC_002516.2

Gene: PA5242 ppk Structure source: AlphaFold UniProt P0DP44
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Amino acids 736
Annotations 7
Features 28
PDB binders 0
Druggability 0.813

Overview

Basic information about this protein and its source genome.

Accession
PA5242
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5242 ppk
Status
annotated
Amino acids
736
Structure source
AlphaFold
EC
2.7.4.1
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009358 A protein complex that possesses polyphosphate kinase activity. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion. GO:0008976 Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0006799 The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.813
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009358 A protein complex that possesses polyphosphate kinase activity.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046872 Binding to a metal ion.
  • GO:0008976 Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).
  • GO:0006799 The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
377 540 CDD cd09165 PLDc_PaPPK1_C1_like
365 548 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
50 154 SUPERFAMILY SSF140356 PPK N-terminal domain-like
50 154 InterPro IPR036832 Polyphosphate kinase N-terminal domain superfamily
156 361 SUPERFAMILY SSF143724 PHP14-like
377 540 Pfam PF17941 Polyphosphate kinase C-terminal domain 1
377 540 InterPro IPR041108 Polyphosphate kinase, C-terminal domain 1
53 158 Pfam PF13089 Polyphosphate kinase N-terminal domain
53 158 InterPro IPR025198 Polyphosphate kinase N-terminal domain
169 369 Pfam PF02503 Polyphosphate kinase middle domain
169 369 InterPro IPR024953 Polyphosphate kinase middle domain
362 544 SUPERFAMILY SSF56024 Phospholipase D/nuclease
159 352 Gene3D G3DSA:3.30.1840.10 Polyphosphate kinase middle domain
159 352 InterPro IPR036830 Polyphosphate kinase middle domain superfamily
546 708 CDD cd09168 PLDc_PaPPK1_C2_like
23 734 PIRSF PIRSF015589 PPK_bact
23 734 InterPro IPR003414 Polyphosphate kinase
552 730 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
55 158 Gene3D G3DSA:1.20.58.310 -
33 729 PANTHER PTHR30218 POLYPHOSPHATE KINASE
33 729 InterPro IPR003414 Polyphosphate kinase
548 727 SUPERFAMILY SSF56024 Phospholipase D/nuclease
53 726 NCBIfam TIGR03705 polyphosphate kinase 1
53 726 InterPro IPR003414 Polyphosphate kinase
549 716 Pfam PF13090 Polyphosphate kinase C-terminal domain 2
549 716 InterPro IPR025200 Polyphosphate kinase C-terminal domain 2
52 730 Hamap MF_00347 Polyphosphate kinase [ppk].
52 730 InterPro IPR003414 Polyphosphate kinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5242
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.307