Protein profile

PA5245

glutamine amidotransferase

Genome: NC_002516.2

Gene: PA5245 Structure source: AlphaFold UniProt Q9HTU9
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Amino acids 222
Annotations 1
Features 11
PDB binders 0
Druggability 0.676

Overview

Basic information about this protein and its source genome.

Accession
PA5245
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5245
Status
annotated
Amino acids
222
Structure source
AlphaFold
GO
GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
57.143
Human E-value
1.29e-35
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.676
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MHKKVAVILSGCGVYDGAEIHESVITLLRLSQRGAEAQCFAPNIAQHHVVNHLTGEEMPESRNVLVESARIARGEVKDLREARAEDYDALIVPGGFGAAKNLSDFAINGAQCQVQPDVLALAKAFAEAGKPVGLICIAPAMAAKIYGAGVQCTIGNDADTADALKQMGAEHIDAPVDEIVEDSARKLVTTPAYMLAQSIAEAASGINKLVDRVLELVDQDKA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
5 217 CDD cd03133 GATase1_ES1
1 222 Gene3D G3DSA:3.40.50.880 -
1 222 InterPro IPR029062 Class I glutamine amidotransferase-like
2 218 FunFam G3DSA:3.40.50.880:FF:000032 Glyoxalase
16 189 Pfam PF01965 DJ-1/PfpI family
16 189 InterPro IPR002818 DJ-1/PfpI
3 217 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
3 217 InterPro IPR029062 Class I glutamine amidotransferase-like
3 217 PANTHER PTHR10224 ES1 PROTEIN HOMOLOG, MITOCHONDRIAL
2 217 PIRSF PIRSF006320 Elb2
2 217 InterPro IPR026041 Glyoxalase ElbB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5245
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.676