Protein profile

PA5246

hypothetical protein

Genome: NC_002516.2

Gene: PA5246 Structure source: AlphaFold UniProt Q9HTU8

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Amino acids 157

Annotations 2

Features 9

PDB binders 0

Druggability 0.877

Overview

Basic information about this protein and its source genome.

Accession: PA5246
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5246
Status: annotated
Amino acids: 157
Structure source: AlphaFold

3.1.2.20

GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.877

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

3.1.2.20

Gene Ontology (GO)

GO:0047617 Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
29	155	CDD	cd03443	PaaI_thioesterase
10	156	Gene3D	G3DSA:3.10.129.10	Hotdog Thioesterase
58	148	Pfam	PF03061	Thioesterase superfamily
58	148	InterPro	IPR006683	Thioesterase domain
27	155	NCBIfam	TIGR00369	hotdog fold thioesterase
27	155	InterPro	IPR003736	Phenylacetic acid degradation-related domain
5	155	SUPERFAMILY	SSF54637	Thioesterase/thiol ester dehydrase-isomerase
5	155	InterPro	IPR029069	HotDog domain superfamily
21	156	PANTHER	PTHR43240	1,4-DIHYDROXY-2-NAPHTHOYL-COA THIOESTERASE 1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5246	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.877
1				0.337