Protein profile

PA5248

hypothetical protein

Genome: NC_002516.2

Gene: PA5248 Structure source: AlphaFold UniProt Q9HTU6
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Amino acids 633
Annotations 9
Features 41
PDB binders 0
Druggability 0.791

Overview

Basic information about this protein and its source genome.

Accession
PA5248
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5248
Status
annotated
Amino acids
633
Structure source
AlphaFold
GO
GO:0033573 A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0015093 Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.791
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9
  • GO:0033573 A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0015093 Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0046872 Binding to a metal ion.
  • GO:0034755 A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
  • GO:0005381 Enables the transfer of iron (Fe) ions from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
18 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
399 409 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
473 496 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
410 432 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
370 631 PANTHER PTHR31632 IRON TRANSPORTER FTH1
370 631 InterPro IPR004923 Iron permease FTR1/Fip1/EfeU
442 461 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
433 443 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 372 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
541 551 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
342 475 Pfam PF03239 Iron permease FTR1 family
342 475 InterPro IPR004923 Iron permease FTR1/Fip1/EfeU
599 617 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
410 432 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
497 515 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
474 496 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
552 574 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 220 Gene3D G3DSA:1.10.760.10 -
102 220 InterPro IPR036909 Cytochrome c-like domain superfamily
131 213 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
131 213 InterPro IPR009056 Cytochrome c-like domain
376 398 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
551 573 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
462 472 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
129 217 ProSiteProfiles PS51007 Cytochrome c family profile.
129 217 InterPro IPR009056 Cytochrome c-like domain
516 540 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
444 461 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
599 617 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
516 538 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
618 633 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
373 398 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
575 598 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
119 223 SUPERFAMILY SSF46626 Cytochrome c
119 223 InterPro IPR036909 Cytochrome c-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5248
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.791
4 0.778
2 0.662
3 0.379