Protein profile

PA5253

alginate regulatory protein AlgP

Genome: NC_002516.2

Gene: algP algR3 PA5253 Structure source: AlphaFold UniProt P15276
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Amino acids 352
Annotations 5
Features 7
PDB binders 0
Druggability 0.556

Overview

Basic information about this protein and its source genome.

Accession
PA5253
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
algP algR3 PA5253
Status
annotated
Amino acids
352
Structure source
AlphaFold
GO
GO:0009986 The external part of the cell wall and/or plasma membrane. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:1900190 Any process that modulates the frequency, rate or extent of single-species biofilm formation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.556
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0009986 The external part of the cell wall and/or plasma membrane.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:1900190 Any process that modulates the frequency, rate or extent of single-species biofilm formation.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
156 352 MobiDBLite mobidb-lite consensus disorder prediction
329 352 MobiDBLite mobidb-lite consensus disorder prediction
2 133 NCBIfam NF038178 AlgP family protein N-terminal domain
2 133 InterPro IPR047725 Transcriptional regulator AlgP, N-terminal domain
74 94 Coils Coil Coil
34 68 Coils Coil Coil
128 336 PANTHER PTHR44826 SPORE COAT PROTEIN SP85

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5253
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.556
2 0.237