Protein profile

PA5255

anti-RNA polymerase sigma 70 factor

Genome: NC_002516.2

Gene: PA5255 algR2 algQ Structure source: AlphaFold UniProt P15275
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Amino acids 160
Annotations 5
Features 6
PDB binders 0
Druggability 0.577

Overview

Basic information about this protein and its source genome.

Accession
PA5255
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5255 algR2 algQ
Status
annotated
Amino acids
160
Structure source
AlphaFold
GO
GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). GO:0045861 Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. GO:1900192 Any process that activates or increases the frequency, rate or extent of single-species biofilm formation. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.577
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
  • GO:0045861 Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
  • GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
  • GO:1900192 Any process that activates or increases the frequency, rate or extent of single-species biofilm formation.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 153 Gene3D G3DSA:1.20.120.1370 Regulator of RNA polymerase sigma(70) subunit, domain 4
1 153 InterPro IPR038309 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ superfamily
1 155 PIRSF PIRSF016548 Rsd_AlgQ
1 155 InterPro IPR007448 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ
1 145 Pfam PF04353 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ
1 145 InterPro IPR007448 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5255
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.577
1 0.263