Protein profile

PA5258

hypothetical protein

Genome: NC_002516.2

Gene: PA5258 Structure source: AlphaFold UniProt Q9HTT7

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Amino acids 376

Annotations 0

Features 11

PDB binders 0

Druggability 0.812

Overview

Basic information about this protein and its source genome.

Accession: PA5258
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA5258
Status: annotated
Amino acids: 376
Structure source: AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.812

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
35	55	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	28	MobiDBLite	mobidb-lite	consensus disorder prediction
1	34	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	26	MobiDBLite	mobidb-lite	consensus disorder prediction
56	376	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
71	91	Coils	Coil	Coil
3	370	PANTHER	PTHR38043	PROTEIN HEMX
3	370	InterPro	IPR007470	Putative uroporphyrinogen-III C-methyltransferase HemX
34	56	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
130	358	Pfam	PF04375	HemX, putative uroporphyrinogen-III C-methyltransferase
130	358	InterPro	IPR007470	Putative uroporphyrinogen-III C-methyltransferase HemX

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA5258	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.656
7				0.654
8				0.349
11				0.299